Abstract
The National Comprehensive Cancer Network (NCCN) 2018 Clinical Practice Guidelines in Oncology for basal cell carcinoma (BCC) identifies risks factors for recurrence of BCCs and classifies tumors as high, medium, or low risk based on tumor characteristics such as location, histologic subtype, size, and prior treatment (see section “Introduction” in Chap. 4). Based on the NCCN recommendations, superficial therapies such as topical therapies, cryotherapy (CT), and photodynamic therapy (PDT) should be considered in low-risk, superficial BCCs in patients where surgical therapy (ST) and radiotherapy (RT) are contraindicated or impractical. In this chapter, PDT will be discussed as a nonsurgical treatment option for BCC. Additional nonsurgical treatment options including topical therapies, CT, electrodesiccation and curettage (ED&C), laser therapy (LT), RT, intralesional therapy, and systemic therapy such as targeted therapy and immunotherapy will be discussed in other chapters (see Chaps. 4, 6, 12, 10, 5, 13, and 14).
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