Abstract
Photodynamic therapy (PDT) is a modality for the treatment of various tumors. Although PDT has been proposed as an alternative in overcoming multi-drug resistance, the impact of Photofrin-mediated PDT on cisplatin-resistant cells has not been addressed thus far. We established two new human primary squamous cell carcinoma derived cell lines and its cisplatin-resistant subline to investigate resistance mechanisms. We investigated the efficacy of Photofrin-mediated PDT on cells which were cisplatin-sensitive and -resistant phenotype. The 50% inhibitory concentration (IC 50) showed no statistically significant difference between both parent cell and its resistant subline. Twenty-four hours after PDT, both parent and cisplatin-resistant sublines showed the same DNA content pattern. The data reported in this study show that Photofrin-mediated PDT revealed equal photo-cytotoxicity in both sensitive and cisplatin-resistant cells.
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