Abstract
Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. In early stages of the disease, topical therapeutic approaches like steroids, chemotherapy, phototherapy or spot radiation therapy are most commonly used. Photodynamic therapy (PDT) is widely executed in the treatment of actinic keratosis and superficial basal cell carcinoma. The effective use of PDT for early forms of MF has been previously demonstrated in a series of cases. In this instance, the treatment of MF (n = 6, 11 lesions) with methyl alanine PDT (MAL-PDT) in 73% of the treated lesions showed a complete response. Within the timeframe of 25-51 months, no recurrence of the successfully treated lesions was observed, on the contrary some of the patients developed new lesions on different sites. Hence, this case study shows that patients having a single or few MF lesions can be successfully treated by PDT.
Highlights
Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of malignant T lymphocytes arising primarily in the skin [1]
While the early form is characterized by localized skin lesions such as red patches and plaques, late stages can be identified by generalized patches, plaques, tumors and erythroderma [2]
Patients with early forms of mycosis fungoides (MF), i.e. localized patches and plaques covering less than 10% of the body surface, have an excellent prognosis with the potential for a longer life-span
Summary
Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of malignant T lymphocytes arising primarily in the skin [1]. The most common form is mycosis fungoides (MF). While the early form is characterized by localized skin lesions such as red patches and plaques, late stages can be identified by generalized patches, plaques, tumors and erythroderma [2]. Patients with early forms of MF, i.e. localized patches and plaques covering less than 10% of the body surface, have an excellent prognosis with the potential for a longer life-span. Patients with generalized form have a high risk of disease progression leading to death [3]. Until now there are no curative options and all therapies aim to relieve the patients from the symptoms that accompany either form of MF. The current treatment modalities for localized forms are highly potent topical steroids, chemotherapy, phototherapy and radiation therapy [4]
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