Abstract
CANCER IN BARRETT'S ESOPHAGUS. Ber qein F. Overholt and Masoud Panjehpour. Thompson Cancer Survival Center, Knoxville, TN. PURPOSE. This report presents the results of photodynamic therapy (PDT) in 30 patients with Barrett's esophagus and dysplasia. Fourteen (14) of these patients also had superficial esophageal cancer. METHODS. Twenty three patients had high grade dysplasia (HGD), 7 had low grade dysplasia (LGD), 12 had Tis-T1 cancer and 2 had T2 cancer. All patients received PDT using sodium porfimer as the photosensitizer and 630nm light delivered endoscopically using a diffuser or a centering balloon. All but 1 were treated as outpatients. Follow-up ranged from 6-60 months. Two patients required 3 separate PDT sessions, 7 required 2 sessions and the remaining 21 patients were treated once. All patients were maintained on omeprazole, 20 mg b.i.d, for 3 months, then 20 mg daily for 9 months. RESULTS. Superficial cancer was eliminated in all 14 patients. Dysplasia was eliminated in 19 patients and reduced from HG to LG in 4. One patient has progressed from LG to HG dysplasia.
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