Abstract
The synthesis, characterization and photodynamic therapy activity of a novel metal free phthalocyanine (complex 3), with or without silver nanoparticles (AgNPs), are reported. The in vitro photodynamic activity of this complex was investigated using metastatic melanoma cancer cell line. In the presence of different concentrations of complex 3 or 3 in combination with silver nanoparticles, the viability of the cells showed a concentration dependent decrease upon irradiation with red light. The photodynamic activity of complex 3 showed an increase in the presence of the AgNPs. Although complex showed a high degree of aggregation in water, it still demonstrated reasonable potency towards the melanoma cancer cell line.
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