Abstract
Abstract10‐(4‐Formylphenyl)‐5,15‐bis(pentafluorophenyl)corrole 1 and its gallium complex 1‐Ga were used to investigate their photocytotoxicity in liver cancer (BEL‐7402), lung cancer (A549) and cervical cancer (Siha, Hela) cell lines. Among all the tested tumor cells, Siha tumor cells were the most sensitive to photodynamic therapy (PDT) treatment by 1 and 1‐Ga. PDT IC50 of 1 and 1‐Ga toward Siha tumor cell reaches 1.3 and 0.8 µmol/L respectively, which is 10‐fold higher than that of cisplatin. 1 and 1‐Ga might pass across the tumor cell membrane smoothly without the help of carrier protein, and mainly localized in the cytoplasm of tumor cell. After PDT treatment, the intracellular reactive oxygen species (ROS) level increased and the mitochondrial membrane potential decreased significantly, which would finally result in the apoptosis of tumor cells.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
