Photodynamic inactivation of bacteria: finding the effective targets.

Abstract

. Being the main targets of PDI the external structures, the PS does not need to reach the intracellular compartment since specific and proper adhesion to those structures is adequate for its light-activated destruction. As a consequence, the prob-ability of resistance development in target microorganisms by blocking uptake, increas -ing metabolic detoxification or increasing the export of the drug is minimal