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Abstract
Photodynamic therapy (PDT) is an emerging non-invasive treatment based on a combination of photochemistry and photophysics. PDT has more advantages compared with traditional...
Highlights
Photodynamic therapy (PDT) is an emerging non-invasive treatment based on a combination of photochemistry and photophysics
The photophysical property, cytotoxicity of hematoporphyrin derivative BL-1 in vitro and in vivo were investigated as photosensitizer for photodynamic therapy (PDT)
When the photosensitizer (PS) molecule is illuminated by a light of particular wavelength, it passes from the first excited singlet state to the first excited triplet state T1, which will initiate a photochemical reaction by generating reactive free radicals or transferring its energy to the ground state oxygen molecule (3O2) to produce singlet oxygen (1O2) that can oxidate the bio-molecules of diseased cells and apoptosis or necrosis was resulted [5,6]
Summary
Photodynamic therapy (PDT) is an emerging non-invasive treatment based on a combination of photochemistry and photophysics. The photophysical property, cytotoxicity of hematoporphyrin derivative BL-1 in vitro and in vivo were investigated as photosensitizer for photodynamic therapy (PDT). Strong absorption and high singlet oxygen quantum yield of compound BL-1 were exhibited. Compound BL-1 was suggested as the potential and promising antitumor photosensitizer for PDT. Cytotoxicity of new hematoporphyrin derivative BL-1 in vitro and in vivo were investigated As Photosensitizer for Photodynamic Therapy (PDT).
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