Abstract
Employing 1,3-diphenylisobenzofuran as a probe, the photodynamic activity of a nickel diimine complex, bis(o-diiminobenzosemiquinonato)nickel(II), in red light has been studied by fluorescence spectra. These results show that the nickel complex can generate singlet oxygen efficiently after irradiation in red light. The interaction of the metal complex with DNA has also been studied by electronic absorption spectra, fluorescence spectra and viscosity measurements. The electronic spectra of the metal complex exhibit dramatic hypochromism on interaction with DNA. Scatchard plot analyses indicate that the metal complex can competitively inhibit the binding between DNA and ethidium bromide. Viscosity experiments show that the binding of the metal complex increases the relative viscosity of DNA. These results suggest that the photoactive nickel diimine complex may interact with DNA by intercalation binding mode. Potential applications of the complex in photodynamic therapy are discussed.
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