Abstract
An aqueous solution of chloramphenicol was degraded upon exposure to sunlight, UV, and tungsten light. The major photodegradation products were hydrochloric acid, p-nitrobenzaldehyde, p-nitrobenzoic acid, 4,4′-azoxybenzoic acid, and p-aminophenyl-2-acetamido-1,3-propanediol. Photolysis of p-nitrobenzaldehyde in water gave exclusively one product, p-nitrosobenzoic acid, with 92% yield. The data obtained suggest that p-nitrosobenzoic acid may be an intermediate in the reaction mixture of chloramphenicol. Photolysis of chloramphenicol in ethanol and benzene was also similarly conducted. No degradation products were found. The chemistry of the photodegradation products suggests that chloramphenicol in water under the influence of light undergoes oxidation, reduction, and condensation reactions.
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