Abstract
AbstractDecomposition of gossypol as a thin film or as a solution by ultraviolet irradiation was studied. The decomposition of gossypol followed monophasic exponential kinetics in which the rate of decomposition varied and depended upon the irradiation condition. The lowest rate of gossypol decomposition was observed as a thin film which showed a half‐life of 97 min, while the highest rate was attained as a solution in acetone as indicated by a half‐life of 4.5 min. Solutions in methanol and ethanol showed relatively lower rates of decomposition with similar half‐lives of approximately 50 min. Acetonitrile and chloroform solutions showed intermediate rates of decomposition for gossypol with half‐lives of 15 and 19 min, respectively. Although the degradation products of gossypol were not identified, their HPLC profiles were characteristic of the solvent used. HPLC profiles of gossypol degradation products in methanol, ethanol, acetone and acetonitrile were similar, each exhibiting two peaks with variable ratios depending on the solvent and the time of exposure. The degradation products of gossypol when irradiated as a thin film and as a solution in chloroform were different from those in other solvents. In all cases, when gossypol and/or its degradation products were continuously exposed to ultraviolet radiation, they decomposed to products no longer having an aromatic structure.
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