Photocurable Bioink for the Inkjet 3D Pharming of Hydrophilic Drugs.

Giovanny Acosta-Vélez,Madison Craig,Benjamin Wu,Chase Linsley

doi:10.3390/bioengineering4010011

Giovanny Acosta-Vélez, Madison Craig + Show 2 more

Open Access

https://doi.org/10.3390/bioengineering4010011

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Journal: Bioengineering	Publication Date: Jan 28, 2017
Citations: 38	License type: CC BY 4.0

Affiliation: University of California, Los Angeles

Abstract

Novel strategies are required to manufacture customized oral solid dosage forms for personalized medicine applications. 3D Pharming, the direct printing of pharmaceutical tablets, is an attractive strategy, since it allows for the rapid production of solid dosage forms containing custom drug dosages. This study reports on the design and characterization of a biocompatible photocurable pharmaceutical polymer for inkjet 3D printing that is suitable for hydrophilic active pharmaceutical ingredients (API). Specifically, hyaluronic acid was functionalized with norbornene moieties that, in the presence of poly(ethylene) glycol dithiol, Eosin Y as a photoinitiator, and a visible light source, undergoes a rapid step-growth polymerization reaction through thiol-ene chemistry. The engineered bioink was loaded with Ropinirole HCL, dispensed through a piezoelectric nozzle onto a blank preform tablet, and polymerized. Drug release analysis of the tablet resulted in 60% release within 15 min of tablet dissolution. The study confirms the potential of inkjet printing for the rapid production of tablets through the deposition of a photocurable bioink designed for hydrophilic APIs.

Highlights

Pharmaceutical dosages are set in the early clinical trial phase and are defined by the amount of active pharmaceutical ingredient (API) with a therapeutic effect in the most number of patients [1]
Technology that: (1) can operate at drug dispensing locations, such as pharmacies and hospitals; (2) is economically viable; (3) dispenses precise drug dosages; and (4) has a short production time is required. 3D printing is one such technology. 3D Pharming—the direct printing of pharmaceutical tablets [4]—offers a viable alternative to fabricate personalized dosage forms over traditional tablet manufacturing techniques, such as direct powder compression where the best case is that a tablet can be split into smaller sections as a way to individualize dosages
The carboxyl groups in Hyaluronic acid (HA) were conjugated with acid dihydrazide (ADH) by using the carbodiimide ethyl-3-(dimethylaminopropyl) carbodiimide hydrochloride (EDC) as coupling agent

Summary

Introduction

Pharmaceutical dosages are set in the early clinical trial phase and are defined by the amount of active pharmaceutical ingredient (API) with a therapeutic effect in the most number of patients [1]. This “one size fits all” approach fails to account for physiological differences and genomic diversity among the patient population [2]. Previous studies have used 3D printing technologies to control a drug’s location within a tablet, the drug release kinetics, and to load multiple APIs within a single tablet [5,6,7,8]

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