Abstract
Extracellular pH is a regulatory gauge for numerous cellular processes in the human body. Acid-sensing ion channels (ASICs) act as a detector for changes in extracellular pH, activating in the presence of acidification. This family of ligand-gated ion channels is a critical player in a myriad of physiological and pathophysiological conditions, including ischemia and pain. As such, determining the molecular innerworkings of how these channels translate acidification into channel activation is of particular interest for therapeutic development.
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