Abstract
Novel photoresponsive systems for site-selective RNA scission have been prepared by combining metal ions with DNA bearing an azobenzene adjacent to an acridine. The modified DNA forms a heteroduplex with the substrate RNA, and selectively activates the phosphodiester linkages in front of the acridine, only when the azobenzene is isomerized into cis form by UV irradiation. Trans-azobenzene, on the other hand, effectively suppresses the reaction. As a result, 1.7-2.4-fold acceleration of the cleavage was achieved only with 3 min UV irradiation.
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