Abstract
New molecules incorporating a uracil nucleic base and a dihydroindolizine (DHI) unit linked via spacer arms, i.e., uracil-spyrodihydroindolizine ( 4), were synthesised as models for light sensitive systems for nucleic acid labelling. The uracil-DHI ( 4) undergoes easy photocoloration to the uracil-betaine ( 5) generating the UV-detectable species. Preliminary results show rather weak binding of uracil-DHI ( 4) to calf thymus-DNA.
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Schedule a callMore From: Journal of Photochemistry & Photobiology, B: Biology
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