Abstract
Abstract Photochemistry of an anticancer drug flutamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl] propanamide has been investigated in various media in the absence and presence of 0.1 T magnetic field. On photoexcitation flutamide gives rise to a phenol derivative through nitro-to-nitrite rearrangement in homogeneous as well as in inhomogeneous solutions. Magnetic field effects on the product yields revealed that a radical pair is involved in the photoreduction, where the excited triplet state of flutamide is the precursor of the pair. It undergoes hydrogen abstraction reaction in inhomogeneous solutions where solvent molecules act not only as component of solvent cage but also as hydrogen donor.
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More From: Journal of Photochemistry and Photobiology A: Chemistry
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