Abstract
Carbon disulfide (CS2) is thought to be a biologically relevant molecule that, upon reacting with amines, forms dithiocarbamates, which disrupt nuclear factor κB mediated tumor growth. To insure careful control we have designed a photocatalytic system whereby CS2 uncaged from the surface of binary chalcogenide cadmium selenide (CdSe) nanocrystalline quantum dots (QD). This is achieved through a hole transfer process to 1,1-dithiooxalate (DTO) adsorbed to the nanoparticle surface after exciting the QD with visible and near UV light. An analogous photoreaction occurs with the t-butyl- DTO ester. We have also synthesized an octyl-DTO ester through an acetylation and a subsequent sulfur replacement reaction with chloride substituents. These esters provide a modular system where the photochemical breakdown of the DTO compound could release additional therapeutics. Currently, we are working to synthesize a dye-functionalized DTO ester to further understand this photochemical process and product distribution. Th...
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