Abstract
The photochemical properties of gemifloxacin (GEFX), a fluoroquinolone antibacterial drug that exhibits phototoxicity toward biological substrates, were studied in aqueous solutions by laser flash photolysis (LFP) and pulse radiolysis. GEFX triplet state (3GEFX∗) absorption spectra showed maximum absorption at 510nm. 3GEFX∗ was quenched by naproxen (NAP) via energy transfer with a rate constant of 1.2×108dm3mol−1s−1. The energy of 3GEFX∗ was 266kJmol−1 and the transient absorption spectra showed direct evidence of electron transfer from 2′-deoxyguanosine-5′-monophosphate, N,N,N′,N′-tetramethyl-p-phenylenediamine, and tryptophan to 3GEFX∗ with bimolecular reaction rate constants of 4.1×106, 2.0×107, and 2.2×107dm3mol−1s−1, respectively. The rate constants for reactions of GEFX with OH, eaq− were found to be 1.5×1010 and 1.4×1010dm3mol−1s−1, respectively. The mechanisms and products of the photosensitive damage of lysozyme were related to the GEFX concentration, irradiation time, and ambient conditions.
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