Photochemical properties and promising activity against staphylococci of sulfanyl porphyrazines with dendrimeric moieties

Abstract

Magnesium(II) porphyrazines bearing dendrimeric 3,5-dimethoxybenzylthio, 3,5-bis(3,5-dimethoxybenzyloxy)benzylthio, 3,5-bis[(3,5-bis((3,5-dimethoxybenzyloxy)-benzyloxy]benzylthio groups were studied as photosensitizers against bacteria typically found in wounds. They revealed intensive absorbance in the UV–Vis spectra. Singlet oxygen quantum yields of sulfanyl porphyrazines were low and appeared in the range between 0.01 and 0.05. In the photodegradation study, all macrocycles decomposed under light irradiation with the photodecomposition quantum yields up to 1.90 ∙ 10-5. For the antimicrobial photodynamic activity studies, sulfanyl porphyrazines were loaded into liposome carriers. Significant photodynamic activities of macrocycles against Staphylococcus aureus with 4.6 log and Staphylococcus epidermidis with 3.5 log were observed.