Abstract
Due to the high bond dissociation enthalpies (BDE) of the C–F bond, defluorinative functionalization of CF 3 groups via the formation of fluoroalkyl radicals is a long-standing challenge in organic synthesis. In a recent paper published in JACS, Molander and co-workers described a powerful photochemical defluorinative functionalization of polyfluorinated carbonyls via spin-center shift (SCS). The key to success was a rationally designed photochemical HAT-mediated formation of CO 2 •− and utilization of the reducing power of CO 2 •− to accomplish the reduction of challenging substrates that are centered around the ability of alkyl thiol catalysts to shuttle hydrogen atoms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
