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Abstract
It has been postulated that in the metabolism of chloramphenicol, nitroso compounds can be formed in the “predisposed host”. This would be the cause of non-dose-related aplastic anemia. Solid proof for this metabolic formation in vivo has not been given. However, on exposure to sunlight under in vivo-related circumstances, relevant to the eye under treatment, we found beside p-nitrobenzaldehyde, p-nitrobenzoic acid and p-nitrosobenzoic acid. The latter even up to 45 mol% of the starting amount of chloramphenicol. This photoreaction is not restricted to the eye but may also occur in the skin.
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