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Abstract
The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers. Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy)2LX]n+, where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO+ and NO2− was investigated employing spectroscopic and electrochemical techniques. The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [RuIIH2O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea. The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.
Highlights
During the last decades, a large number of studies concerned with NO activity in biological systems have been published revealing novel physiological roles and promising therapeutical applications.[1,2,3,4,5,6,7,8,9,10] The NO molecule is the smallest well-known biological messenger that does not depend on specific transporters.[11]
These results are in good agreement with the quantum yield data, where the highest φ for the formation of the RuII‐OH2 species was observed for the [Ru(bpy)2(1-meimN)NO]3+ complex, which presents the highest percentage of NO release quantified by square wave voltammetry (87.1%)
Square-wave voltammetry has been shown a reliable analytical tool for quantitative measurements of the amount of nitric oxide released, important when working with slow-releasing compound
Summary
A large number of studies concerned with NO activity in biological systems have been published revealing novel physiological roles and promising therapeutical applications.[1,2,3,4,5,6,7,8,9,10] The NO molecule is the smallest well-known biological messenger that does not depend on specific transporters.[11].
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