Abstract
AbstractSulfoximines, the isoelectronic with sulfones, represent a class of alternative and intriguing motifs in both discovery program and agrochemistry. N‐Alkylation on imines could significantly improve their bioactivities, but the lack of general method has hindered their further uptake by medicinal chemistry and drug development. Herein, we present a mild photocatalytic anti‐Markovnikov hydroamination of alkenes to construct N‐alkylated sulfoximines with broad substrate tolerance on primary, secondary and tertiary alkyl substituents as well as a diverse range of sulfoximines. The mechanistic studies support the photocatalytic pathway, and demonstrate that the alkene radical cation rather than the iminium radical serves as the key intermediate in the transformation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
