Abstract
Cancer Immunotherapy In article number 2210986, Mingming Ding and co-workers construct a photoallosteric polymersome (PAP) that undergoes a rapid conformational transition from β-sheet to α-helix upon exposure to near-infrared light irradiation. Photoinduced allosteric behavior specifically enhances cell penetration and lysosome escape and reconstructs the vesicular membrane structure for on-demand release of hydrophilic and hydrophobic drugs, thus remolding the immune microenvironment and achieving excellent synergistic anticancer efficacy in vivo without tumor recurrence and metastasis.
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