Abstract
Tritiated DTLET (Tyr-D-Thr-Gly-Phe-Leu-Thr) binds with high affinity, specificity and saturability to neuroblastoma N18TG 2 and hybrid neuroblastoma × glioma NG108-15 and NG 108-5 intact cells. The δ-opioid receptor density in cells cultured in chemically defined medium was increased about 2 times compared to that in cells cultured in 10% fetal calf serum. A major and a minor protein species covalently and specifically bound to [ 125I]azido-DTLET (Tyr-D-Thr-Gly-pN 3Phe-Leu-Thr), photoactivatable ligand, migrated on SDS-gel electrophoresis with M r, values near 33000 and 58000, respectively.
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