Photoactivatable poly(2-oxazoline)s enable antifouling hydrogel membrane coatings

Abstract

In recent years, hydrophilic poly(2-oxazoline)s have been examined as an alternative polymer to poly(ethylene glycol) (PEG) with added stability and chemical versatility. They show excellent anti-fouling properties and, like PEG, are of interest in many fields where bio-inertness or anti-adhesiveness are important such as for medical devices, tissue engineering, biosensors, or drug delivery carriers. Surprisingly few studies have utilized this polymer class for the preparation of anti-fouling membranes. Here we describe a new termination reaction of the living cationic ring-opening polymerization of 2-oxazolines in which a benzophenone group is introduced as a photoactivatable terminal head group of poly(2-oxazoline)s. Using 4-vinylbenzyl chloride as initiator, heterotelechelic poly(2-methyl-2-oxazoline) (PMOXA) macromonomers were synthesized and copolymerized with hydroxyl-functional PMOXA macromonomers to yield photoactivatable PMOXA-based prepolymer bottle brushes. Likewise, star-PMOXAs were synthesized by using a trifunctional initiator. Photoactivatable PMOXA prepolymers allowed us to readily form anti-fouling hydrogels by a simple and versatile CH-insertion cross-linking (CHic) process. Hydrogels were applied to poly(ether sulfone) ultrafiltration membranes as pore coating and the pure water permeance (PWP) was investigated as a function of hydrogel architecture and cross-link density. Anti-fouling hydrogel pore-coated membranes having PWPs on the order of hundred kg·m−2·h−1·bar−1 were obtained.