Abstract
(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994) binds with high affinity (pK i 9.6) to the human NK 1 receptor. Racemic analogues of CP-99,994 containing either benzoyl or diazirinyl moieties also bind with high affinity (pK i 9.4 and 9.1 respectively). These analogues are of tremendous potential for mapping the antagonist binding site of the NK 1 receptor.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.