Abstract
Since changes in mechanical properties of biological tissues are often closely related to pathology, the viscoelastic properties are important physical parameters for medical diagnosis. A photoacoustic (PA) phase-resolved method for noninvasively characterizing the biological tissue viscoelasticity has been proposed by Gao et al. [G. Gao, S. Yang, D. Xing, “Viscoelasticity imaging of biological tissues with phase-resolved photoacoustic measurement,” Opt. Lett. 36, 3341–3343 (2011)]. The mathematical relationship between the PA phase delay and the viscosity–elasticity ratio has been theoretically deduced. Moreover, systems of PA viscoelasticity (PAVE) imaging including PAVE microscopy and PAVE endoscopy were developed, and high-PA-phase contrast images reflecting the tissue viscoelasticity information have been successfully achieved. The PAVE method has been developed in tumor detection, atherosclerosis characterization and related vascular endoscopy. We reviewed the development of the PAVE technique and its applications in biomedical fields. It is believed that PAVE imaging is of great potential in both biomedical applications and clinical studies.
Highlights
IntroductionAs one of the fastest growing imaging technologies, photoacoustic (PA) imaging provides excellent opportunities for in vivo characterization of disease pathophysiology.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19] It overcomes the resolution disadvantages of pure optical imaging and the contrast disadvantages of pure ultrasound imaging, beneting from the capacity of high-resolution
The PA viscoelasticity (PAVE) imaging technique has been applied to tumor detection,[43] atherosclerosis characterization[44,45,46] and vascular endoscopy.[47]
PAVE imaging dedicated to biological tissues mechanical characterization seen from Eq (2), the phase delay is closely related to the viscoelastic properties of biological tissues
Summary
As one of the fastest growing imaging technologies, photoacoustic (PA) imaging provides excellent opportunities for in vivo characterization of disease pathophysiology.[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19] It overcomes the resolution disadvantages of pure optical imaging and the contrast disadvantages of pure ultrasound imaging, beneting from the capacity of high-resolution. In view that changes in biological tissues are often closely related to pathology, the viscoelastic properties are important physical parameters for medical diagnosis.[40,41] the PA technique that characterizes the viscoelasticity of tissues is of great potential in medical applications and clinical research. The PAVE imaging technique has been applied to tumor detection,[43] atherosclerosis characterization[44,45,46] and vascular endoscopy.[47] It is believed that PAVE imaging has great potential in both biomedical applications and clinical studies. We review the development of the PAVE technique and its applications in biomedicalelds
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