Abstract
We exposed aggressive 4T1 tumors to photoacoustic waves with the aim to increase the concentration of a photosensitizer in the tumors and improve the outcome of photodynamic therapy (PDT). The photoacoustic waves were generated using a material that efficiently converts laser pulses into high-amplitude ultrasound pulses, and their effect in tumor priming were assessed using photoacoustic tomography. After the redaporfin injection and tumor priming with photoacoustic waves, the tumors were treated with light, leading to a significant increase in the survival of the mice compared to untreated. These results suggest that photoacoustic tumor priming can improve the efficacy of PDT, and may be a promising strategy for enhancing drug delivery to solid tumors.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
