Abstract
In some diseases the accumulated endogenous δ-aminolevulinic acid (δ-ALA), with a pH between 7 and 8, undergoes an enolization process that produces free radicals. It is expected that most of the exogenously-supplied δ-ALA in healthy organisms will be converted into protoporphyrin IX (PpIX), and ultimately to the hem group, but a small accumulation of δ-ALA, when present, will initiate a lipid peroxidation process due to the generation of oxygen-reactive species. Some of the end products commonly found in lipid peroxidation include ethane, pentane, and ethylene as well as other hydrocarbons. As these gases are normally produced at trace levels, sensitive techniques are needed for their measurement. In this work, the peroxidative effect of exogenously-supplied δ-ALA and CCl4 in female CD1 mice has been studied by photoacoustic trace gas detection. Exhaled ethylene from δ -ALA-administered mice reached concentrations of few ppbV for approximately 30 minutes, after application of δ-ALA.
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