Abstract
BackgroundStimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. However, it remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis.ResultsWe report a novel photo-responsive degradable hollow mesoporous organosilica nanoplatform (HMONs@GOQD). The platform is based on organosilica nanoparticles (HMONs) containing singlet oxygen (1O2)-responsive bridged organoalkoxysilanes and wrapped graphene oxide quantum dots (GOQDs). The unique hollow mesoporous structure of the HMONs guarantees an excellent drug loading and release profile. During light irradiation, 1O2 produced by the GOQDs leads to the degradation of the organosilica nanoparticles, resulting in enhanced local drug release.ConclusionsWe carried out in vitro and in vivo experiments using DOX as a model drug; DOX-HMONs@GOQDs exhibited high biocompatibility, accelerated degradation, and superior therapeutic efficacy during light irradiation, indicating a promising platform for clinical cancer therapy.
Highlights
Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers
We synthesized the hollow mesoporous organosilica nanoparticles (HMONs) via sol–gel methods using SiO2 as the hard template based on a “structure difference-based selective etching” strategy [55]
The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) images shown in Fig. 1a, b and Additional file 1: Fig. S2 confirm the hollow structure of HOMs
Summary
Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. It remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis. Numerous small-scale DDS (nanoparticles and microparticles) are fabricated using various biocompatible materials, such as organic molecules, lipids, polymers, and inorganic nanomaterials. They enables the targeted delivery of drugs to tumors owing to the engineered surfaces of the DDS and the effect of their enhanced permeability and retention (EPR) of tumor cells [5,6,7,8,9,10]. As well as unique chemical stability, a high surface area, tunable size, and porosity, ideal DDS have biorelated degradability and clearance as essential features. Nanoparticles with the advantages of both organic (biodegradability) and inorganic
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