Abstract
The mitotic kinesin Eg5 has an important role in establishing the bipolar spindle which is directly involved in the cell division. Recently, several small molecules have been identified as potent specific inhibitor of Eg5. STLC is one of the inhibitor which does not compete with either ATP or microtubules but slows down ADP release. STLC binds to the pocket on Eg5 composed by a2, a3 and loop L5. STLC binding induces the downward swing of L5 to close the inhibitor binding pocket. Therefore, L5 is one of the key region to stabilize Eg5-STLC complex.
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