Abstract
Infections are the main cause for delayed wound healing. Graphene oxide (GO) and cerium oxide nanoparticles are used for many biomedical applications because of their biocompatibility and therapeutic property. Cerium Oxide (CeO2)/Graphene Oxide (GO) nanocomposite was synthesized in this work. It shows good antimicrobial property against wound pathogens. The aggregation of CeO2 particles on GO results in the generation of reactive oxygen species (ROS) and inhibits microbial growth. The synthesized nanocomposites were analysed by X-ray diffraction, Transmission electron microscopy, Raman Spectroscopy, UV–vis diffuse reflectance spectroscopy and Fourier transformation-IR spectroscopy. The antimicrobial activity of CeO2/GO nanocomposite was tested against Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) Staphylococcus aureus (S. aureus) and Salmonella typhi (S. typhi). Well diffusion method, growth curve studies, bio film inhibition studies and colony count studies were done in both presence and absence of visible light. The mechanistic investigation was done by the determination of reactive oxygen species (ROS), Lactate dehydrogenase leakage (LDH) assay and DNA fragmentation assay.
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