Abstract
Abstract In order to clarify the functional changes involved in the elevated ratio of cytochrome c + c 1 to cytochrome a(+a 3 ), studies were made of oxidative phosphorylation in mitochondria from regenerating liver of rats treated with chloramphenicol. In the mitochondria from the regenerating liver of rats treated with chloramphenicol of 200 and 400 milligrams per kilogram of body weight every 6 hours, there was a dose-dependent decrease of the contents of cytochromes a(+a 3 ), b, and c 1 , concomitant with an increase in the amount of cytochrome c, resulting in an elevation of the c + c1a(+a3). For example, in rats subjected to chloramphenicol of 400 mg. the ratio of the c + c1a(+a3) increased to 2.32 ± 0.06 (mean ± S.E.) 48 hours after partial hepatectomy as compared with 1.13 ± 0.01 of normal liver mitochondria. Those mitochondria showed considerably higher oxidative and phosphorylative capacities than those of normal mitochondria, despite the marked decrease of cytochromes a(+a 3 ), b, and c 1 . From the results it was suggested that an elevation of a c + c1a(+a3) represents a compensatory mechanism making up ATP.
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