Phosphorylation, Signaling, and Cancer: Targets and Targeting

Sandra Marmiroli,Yoshihiko Miyata,Doriano Fabbro,Mariaelena Pierobon,Maria Ruzzene

doi:10.1155/2015/601543

Abstract

Phosphorylation, Signaling, and Cancer: Targets and Targeting

Highlights

This special issue provides a selection of original articles focused on kinase targets and therapeutic approaches based on kinase targeting in different cell systems and pathological conditions
Powerful broad-scale protein pathway activation mapping and phosphoprofiling of protein kinases and of their specific substrates are contributing to driving the new concept of precision medicine [14,15,16]
The understanding of the mechanisms by which some cancer cells are resistant to ATRA is crucial in anticancer drug development and requires detailed knowledge of the signaling pathways affected by ATRA

Summary

Introduction

Powerful broad-scale protein pathway activation mapping and phosphoprofiling of protein kinases and of their specific substrates are contributing to driving the new concept of precision medicine [14,15,16]. This special issue provides a selection of original articles focused on kinase targets and therapeutic approaches based on kinase targeting in different cell systems and pathological conditions. The understanding of the mechanisms by which some cancer cells are resistant to ATRA (all-trans-retinoic acid) is crucial in anticancer drug development and requires detailed knowledge of the signaling pathways affected by ATRA.

Results

Conclusion