Abstract
Phosphorylation regulates the disassembly of cilia.
Highlights
Cilia and flagella are conserved organelles protruding from the surface of eukaryotic cells and are composed of a ciliary membrane, axoneme, and basal body
Defective ciliary structure and function have been implicated in a spectrum of diseases called ciliopathies, including polycystic kidney disease (PKD), retinal degeneration, respiratory disease, and sterility
*Corresponding author disassembly in 2004, at Professor Snell’s laboratory at the University of Texas Southwestern Medical Center. He and the member in his group in China found that Chlamydomonas aurora-like kinase (CALK) and kinesin-13 (CrKin13) are two important proteins involved in cilia disassembly, while the dissembled products are returned to the cell body via retrograde intraflagellar transport (IFT) [1 3]
Summary
Cilia and flagella are conserved organelles protruding from the surface of eukaryotic cells and are composed of a ciliary membrane, axoneme, and basal body. When cells exit from the cell cycle and enter into the stationary phase (G0), one of the centrioles moves to the apical plasma membrane and differentiates into a basal body, where it functions as a template for the assembly of the cilia axoneme. Prior to entering into the mitosis phase, cilia disassemble, and the basal body reverts to form the centriole, which functions as the center of spindle microtubule organization.
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