Abstract
In this work, we show extensive phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2α) occurring in the brain of mice subjected to 30 min of status epilepticus induced by pilocarpine. eIF2α(P) immunoreactivity was detected in the hippocampal pyramidal layer CA1 and CA3, cortex layer V, thalamus and amygdala. After 2 h of recovery, there was a marked decrease in total brain eIF2α(P), with the cortex layer V showing the most pronounced loss of anti-eIF2α(P) labeling, whereas the CA1 subregion had a significant increase in eIF2α(P). These results indicate that inhibition of protein synthesis in experimental models of epilepsy might be due to low levels of eIF2-GTP caused by the phosphorylation of eIF2α, and suggest that translational control may contribute to cell fate in the affected areas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
