Phosphorylation of β-cyclodextrin with substituted secondary hydroxy groups using phosphorous acid diamide

Abstract

Phosphorylation of β-cyclodextin with substituted secondary hydroxy groups using 1,2-O,O′-isopropylideneglyceryl phosphorous diamide as a phosphorylating agent, in contrast to phosphorylation with trivalent phosphorus acid chlorides, is found to proceeds under mild conditions, but only in homogenous medium, and to afford acyclic diesteroamidophosphite derivatives of β-cyclodextin.