Abstract
Eosinophilic cytoplasmic inclusions in dopaminergic nigrostriatal neurons, the primary component of which is α-synuclein, are the pathological hallmark of Parkinson's disease (PD) [ [1] Hughes A.J. Daniel S.E. Lees A.J. Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease. Neurology. 2001; 57: 1497-1499 Crossref PubMed Scopus (627) Google Scholar ]. Nerve fibers immunoreactive to phosphorylated α-synuclein have been identified in postmortem [ [2] Beach T.J. Adler C.H. Dugger B.N. Serrano G. Hidalgo J. Henry-Watson J. Shill H.A. Sue L.I. Sabbagh M.N. Akiyama H. Arizona Parkinson's Disease Consortium. Submandibular gland biopsy for the diagnosis of Parkinson's disease. J. Neuropathol. Exp. Neurol. 2013; 72: 130-136 Crossref PubMed Scopus (90) Google Scholar ] and in vivo [ [3] Adler C.H. Dugger B.N. Hinni M.L. Lott D.J. Driver-Dunckley E. Hidalgo J. Henry-Watson J. Serrano G. Sue L.I. Nagel T. Duffy A. Shill H.A. Akiyama H. Walker D.G. Beach T.J. Submandibular gland needle biopsy for the diagnosis of Parkinson's disease. Neurology. 2014; 82: 858-864 Crossref PubMed Scopus (99) Google Scholar ] submandibular gland biopsy from PD patients. Here we measured phosphorylated-α-synuclein immunoreactivity in nerve fibers from minor salivary gland biopsy in PD. The study was approved by the “Sapienza” University Ethical Committee .
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