Abstract
Lohith et al. (Mol Autism 4:15, 2013) recently identified increased metabotropic glutamate receptor 5 (mGluR5) expression in the frontal cortex (FC) of subjects with fragile X syndrome. These results are consistent with postmortem findings in cerebellar vermis and FC of subjects with autism (Fatemi and Folsom, Mol Autism 2:6, 2011; Fatemi et al. Anat Rec 294:1635–1645, 2011), suggesting that increased mGluR5 signaling is common to multiple autism spectrum disorders. Increased mGluR5 signaling may be associated with reduced phosphorylation of fragile X mental retardation protein (FMRP), which could result in the inactivation of this protein. In the current study, we report on reduced expression of phosphorylated FMRP in cerebellar vermis of adults and children with autism and in FC of adults with autism.
Highlights
Lohith et al (Mol Autism 4:15, 2013) recently identified increased metabotropic glutamate receptor 5 expression in the frontal cortex (FC) of subjects with fragile X syndrome
We have read with great interest the recent article by Lohith et al [1] regarding increased expression of metabotropic glutamate receptor 5 in the frontal cortex of individuals with fragile X syndrome (FXS)
The results are consistent with our published work of increased expression of metabotropic glutamate receptor 5 (mGluR5) in the superior frontal cortex of children with autism [2]
Summary
Lohith et al (Mol Autism 4:15, 2013) recently identified increased metabotropic glutamate receptor 5 (mGluR5) expression in the frontal cortex (FC) of subjects with fragile X syndrome. The results are consistent with our published work of increased expression of mGluR5 in the superior frontal cortex of children with autism [2].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
