Abstract
The time course of liver phosphorylase activation after catecholamine administration and the relative abilities of several adrenergic blocking agents to block catecholamine-induced phosphorylase activation in liver and skeletal muscle was studied in intact anesthetized rats. Subcutaneously injected epinephrine and norepinephrine increased the liver phosphorylase activity, the peak effect occurring 10 min after injection. The liver phosphorylase levels were somewhat reduced 30 min after injection. Isoproterenol administration did not increase the level of rat liver phosphorylase. Blood glucose changes after catecholamine treatment did not mirror the changes in liver phosphorylase activity. Complete blockade of the liver phosphorylase response to epinephrine was observed with the α-adrenergic blocking agent ergotamine. Phenoxybenzamine and two β-adrenergic blocking agents, dichloroisoproterenol and nethalide, gave partial blockade. These data indicate the difficulty in the classification of the liver metabolic receptor. The activation by epinephrine of skeletal muscle phosphorylase appears to be affected only by β-adrenergic blocking agents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
