Abstract
Magnetic resonance spectroscopy is a relatively new technique for the study of in vivo biochemistry. It offers a look into several biochemical reactions in normally functioning intact tissues. This chapter will not describe the basic NMR experiment and the various atoms that can be studied by it. For an introduction to the NMR field the reader is referred to monographs on the subject (e.g. Gadian [1]). The chapter will also only briefly describe the basics of phosphorus nuclear magnetic resonance spectroscopy (31P NMR). I will concentrate on the use of 31P NMR in muscle mitochondrial disorders and related conditions. Findings in other disorders of energy metabolism (e.g. glycolytic defects) will not be described. Data on normal functioning muscle will be presented only if they are relevant to mitochondrial diseases.
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