Abstract
The intracellular concentration of PP-ribose-P is a balance between its formation and its utilization. Purine nucleosides stimulate PP-ribose-P formation in mammalian cells when inorganic phosphate exceeds 20 mM (1,2). This occurs by the conversion to ribose-5-phosphate of the ribose-1-phosphate liberated from nucleosides by purine nucleoside phosphorylase. Recently Bagnara and Finch (3) showed that nucleosides decreased intracellular PP-ribose-P in Escherichia coli incubated in 1.4 mM inorganic phosphate. The reason for the latter effect has not been clear since there is no substantial direct effect of nucleosides on purified PP-ribose-P synthetase.KeywordsHuman ErythrocyteAdenosine DeaminaseAdenylate KinasePurine NucleosidePurine BaseThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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