Abstract
An original method for the phosphorylation of an unprotected myo-inositol is described, which yields several myo-inositol phosphates at the same time. The reaction proceeds via a partial or complete phosphoranylation of the cyclitol by means of the aminobicyclophosphane 8, followed by oxidation of the resulting bicyclophosphoranes bearing a P—H bond and acid hydrolysis of the neutral phosphates thus formed. In the case of the tris-phosphoranylation we identified, among the HPLC fractions, the myo-inositol-1,2-(cycl)phosphate 22, the myo-inositol-1-phosphate 23, and the myo-inositol-2-phosphate 24.
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