Abstract
Summary Methylation of phospholipids or phosphatidylethanolamine in vivo was greatly reduced in livers of rats or hamsters treated with 3-deazaadenosine. However, it was found that the absolute amounts of phopholipids and phosphatidylcholine remained constant between the livers of control or treated animals. Concomitant with the inhibition of phospholipid methylation, there was a drastic increase in the incorporation of choline into phosphatidylcholine, or phospholipids fraction. In rat liver, the rate of uptake of choline may be determined by its utilization for phosphatidylcholine biosynthesis. These observations suggest intricate control mechanisms regulating phospholipids biosynthesis between methylation pathway and incorporation from choline. In the hamster liver, where 3-deazaadenosylhomocysteine is the major nucleosidylhomocysteine present after administration of 3-deazaadenosine, it is apparent that 3-deazaadenosylhomocysteine exerts an inhibitory potency similar to that of adenosylhomocysteine.
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