Abstract
BackgroundThe plasma activity of phospholipid transfer protein (PLTP), which has multifaceted functions in lipoprotein metabolism and in inflammatory responses, is elevated in insulin resistant conditions. We determined the association of plasma PLTP activity with incident type 2 diabetes mellitus (T2DM). MethodsPlasma PLTP activity was determined using a liposome vesicle–HDL system in 218 men without T2DM at baseline. We used logistic regression models to establish odds ratios (ORs) for incident T2DM. ResultsTwenty four men developed T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM cases (p=0.009). We observed 82% higher odds for T2DM per 1-SD increase in PLTP activity. Multivariable modeling showed that the association of PLTP activity with T2DM was independent of clinical risk factors including age, and either the metabolic syndrome, individual metabolic syndrome components, total cholesterol, HOMA-IR or albuminuria (ORs ranging from 1.64 (95% CI 1.03–2.66) to 1.87 (1.19–3.010)). ConclusionsElevated plasma PLTP activity may predict an increased risk of T2DM in men.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
