Abstract
Antigenic stimulation of rat basophilic leukemia cells sensitized with immunoglobulin E causes the release of histamine as well as arachidonic acid and its metabolites. The release of these substances is preceded by an increase in phospholipid methylation. Inhibition of phospholipid methylation is correlated to the inhibition of histamine release. Inhibition of methylation also reduces arachidonate release. Phospholipid methylation appears to be associated with both histamine secretion and the release of arachidonate and its metabolites.
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