Abstract
DURING work on the metabolism of skin, it was found that a scissors mince of rat skin could incorporate phosphoric acid-32P into the lipid fraction. On completion of the work, our attention was directed to the work of Leonhardi et al. 1, who had found no in vitro synthesis of phospholipid, and had concluded as the result of this and some in vivo feeding experiments that rat skin depended for supplies of phospholipid on the liver via the blood. In view of Zilversmit's2 comment that “rat skin has been shown to be one of the few tissues that cannot synthesize its own phosphatides in vitro”, it has been thought desirable to record some contrary observations that have been made. The point is obviously of major importance in the metabolism of skin.
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