Abstract
The phospholipid distributions in rabbit lens and vitreous humor are remarkably similar to those of rabbit erythrocytes with a predominance of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) and lesser levels of sphingomyelin. A blood-aqueous and blood-vitreous barrier exists for phospholipids. In aqueous humor and vitreous humor, phospholipid concentrations were 1 2 to 1 30 those in serum. Only PE occurs in higher levels in vitreous than in serum, probably reflecting direct diffusion from the retina. Levels of lysophosphatidylcholine (LPC) in rabbit aqueous humor average 4·3 μg/ml. No LPC was present in rabbit lens. The fatty acid composition of PC and LPC was determined in lens, intraocular fluids, and serum. PC from rabbit ocular fluids or lens contains a higher proportion of saturated fatty acids than rabbit serum, and the long chain saturated fatty acids (>22:0) are found only in the ocular fluids.
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