Phospholipase A2

Abstract

Part 1 Structure, distribution and function of phospholipase A2: history, classification, structure and function of phospholipase A2 expression of group II phospholipase A2 in human tissues determinants of the antimicrobial action of 14-kD phospholipase A2 downregulation of cytokine-induced synthesis and secretion of group II phospholipase A2 control of phospholipase A2 gene expression secretory nonpancreatic phospholipase A2 (sPLA2) as a mediator of inflammation. Part 2 Methods for measuring phospholipase A2: catalytic phospholipase A2 assays immunoassay for type II phospholipase A2 specific quantitation of activated pancreatic type phospholipase A2 by measurement of type I prophospholipase A2 propeptide (PROP) secretory PLA2-deficient and transgenic mice in phospholipase A2 research. Part 3 Role of phospholipase A2 in inflammation: eicosanoids as mediators and modulators of allergic reactions phospholipase A2 and acute respiratory distress syndrome phospholipase A2 and oxygen radicals phospholipase A2 in inflamed tissues and inflammatory exudates serum phospholipase A2 in inflammatory diseases phospholipase A2 in experimental acute pancreatitis toxic effects of phospholipase A2 in vitro. Part 4 Inhibition of phospholipase A2: principles of inhibition of phospholipase A2 and other interfacial enzymes new type II phospholipase A2 inhibitors effective in blocking an ongoing enzyme reaction - inability of manoalide and scalaradial to exert an inhibitory capacity structure-based design and therapeutic potential of phospholipase A2 inhibitors marine natural products as phospholipase A2 inhibitors role of cytosolic PLA2, secretory PLA2 and nitric oxide synthase in inflammation inhibition of type II phospholipase A2 in experimental acute pancreatitis - a new specific treatment approach. Part 5 Clinical implications of phospholipase A2: inter-relationship of phospholipase A2 and lipid peroxidation in multisystem organ failure in septic shock phospholipase A2 in acute pancreatitis - clinical value of phospholipase A2 measurements phospholipase A2 in surgical intensive care patients group II phospholipase A2 in neoplastic diseases phospholipase A2 in chronic inflammatory disease of the intestine phospholipase A2 in arthritis phospholipase A2 in psoriasis phospholipase A2 in normal and pathological pregnancies.